Guvendiren Lab

Instructive Biomaterials and Additive Manufacturing Laboratory (IBAM-Lab)

RESEARCH FOCUS AREAS

Research Summary:

 

IBAM-Lab focuses on developing novel polymeric (bio)materials and advanced additive (bio)manufacturing approaches to fabricate functional tissue constructs. These functional constructs enable us to instruct cells to preserve their phenotype or direct their differentiation spatiotemporally. The main applications include tissue-engineered scaffold printing as well as live tissue and organ bioprinting for tissue regeneration (bone, cartilage and osteochondral interface) and tissue/disease models (cancer and liver). With this in mind, we aim to develop bioinks and biomaterial inks, particularly for extrusion-based and vat photopolymerization-based biomaterial printing and bioprinting. We utilize these bioinks or bimaterial inks to manufacture complex living tissues and/or tissue engineering scaffolds enabling 4D control of material properties to recapitulate the dynamic nature of the native tissues and organs.

 

Our group also specializes in controlling surface patterns on 3D printed hydrogels, investigating interlayer adhesion of 3D printed high performance polymers and polymer composites, and developing slurry-based inks from polymer-metal and metal alloy composites towards developing functional advanced materials.

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Ongoing Projects:

 

- Cell-instuctive smart bioinks to fabricate complex tissue interfaces

Funding: NSF CAREER  DMR-2044479 (2021-2026)

 

- Decellulerized extracellular matrix bioinks for musculoskelatal tissue engineering

Funding: MTF Biologics (MTF Junior Investigator Award, 2019-2021)

 

- New biodegradable polymeric biomaterial inks for tissue engineering applications

Funding: NSF DMR-1714882 (2016-2020)

 

Collaborator (Cellulose-based bioinks): Prof. William Gramlich (University of Maine, Orono, ME)

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- In vitro tissue and disease models

We are developing biomaterial platforms with user defined and tunable properties (topography, stiffness, and bioactivity) that could serve as in vitro tissue and/or disease models. These tissue models could help us to better understand tissue development, ageing, disease development and disease progression as well as drug screening. We are currently interested in heart and liver models as well as cancer models. Our expertise is to develop these models. We develop strong collaborations to utilize our models.

Funding: NJ Healthcare Foundation

 

Collaborators:

 

Liver tissue models - Prof. Rebecca G. Wells (Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA)

Heart models - Prof. Eun Lee (BME at NJIT, Newark, NJ)

Cancer models - Prof. Pranela Rameshwar (Rutgers New Jersey Medical School, Newark, NJ)

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- Additively manufactured reactive materials

Funding: DOD

Collaborator: Prof. Ed Dreizin (NJIT)

 

- 4D printing of surface morphing hydrogels

 

- Investigating interlayer adhesion of 3D printed high performance plastics

 

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 All contents copyright © Murat Guvendiren. All rights reserved. (Last updated July 2021)